Description: kground: Abnormally high CSF 3-OMD occurs frequently for RLS patients indicating either increased L-dopa synthesis, limitations
in L-dopa decarboxylation or increased MAT/COMT activity, or some combination of these. Increased tyrosine hydroxylase
activity was found on both the RLS autopsy and the rodent iron-deprivation model of RLS, suggesting increased DA synthesis in
RLS. We, therefore, hypothesized elevated 3-OMD in RLS results from increased DA synthesis and that this should occur accordingly
with increased HVA. It would then also reflect both the more severe iron insufficiency pathology of RLS and greater clinical
severity, shown by the objective measure of PLMS/hr.
Methods: Patients off RLS medications and matched controls had
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